When a handsome, half-naked man staggers into emergency physician Vanessa Franklin's hospital, she does her utmost to save him. Yet he arouses her in ways that she scarcely thought possible. It is as if she had known him, in every way, in some distant time and place.

When the man goes into cardiac arrest, her attempt to defibrillate him hurls her back a century to fogbound London. There, she discovers how she knew the man. His name is Rex Talbot, and in this past life, he and Vanessa are members of a group of vampire-hunters known as The Pentacle.

The past can repeat itself, and to some with the right powers, events can be altered for their selfish gain. Such are the aims of Lord Edgar Beaconsfield, the vampire lord who Vanessa and Rex dispatched once, but whose loyal minions have found a way to resurrect their lord, even if it involves dangerous time travel.

Together, Vanessa and Rex must rediscover how they defeated Lord Beaconsfield, yet their greatest obstacle is their own desires for each other; deprived of each other's body for over a century, their rekindled passion knows no bounds. Little do they realize these desires are worth more than their blood to the vampire lord, and if they fail this time, there might be no future to return to.